Two lanes are closed on the carriageway heading anticlockwise between junction one, for Stockport, and junction two for Cheadle.
Highways England reported that three vehicles crashed on the M60 between the two junctions.
Emergency services were called to the scene on Tuesday morning.
Police, fire crews, traffic officers and paramedics have arrived at the scene of the collision, according to Manchester Evening News.
Motorists are advised to account for delays in their journey times as they travel through the one open lane.
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