Thames Valley Police are attending the incident near Camp Road in Upper Heyford.
The aircraft crashed into an unoccupied block of flats at around midday.
The pilot has been taken to hospital.
There were no other injuries.
Thames Valley Police said: “Thames Valley Police at the scene of a light aircraft crash.
“The aircraft crashed into an unoccupied block of flats near Camp Road in Upper Heyford at about midday.
“The pilot is in hospital but no-one else was injured.
“Anyone with footage or info, call 101 quoting 857 (2/4).”
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